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TiagoLubiana (talk | contribs) (Created page with "== Cell types == What is a cell type? I do not know. We do not know. This wikibase is a shot at formalizing meanings for cell types and cell type descriptors. Properti...") |
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= Cell types = | |||
What is a cell type? | What is a cell type? | ||
This wikibase is a shot at formalizing meanings for cell types and cell type descriptors. | |||
There are, of course, well structured efforts with similar goals, such as the [Cell Ontology https://github.com/obophenotype/cell-ontology]. This is a bit more exploratory, and admittedly less structured. | |||
== Formal criteria == | |||
The notion is that anything that any class of cells that fits the 3 following criteria is formally a cell type: | |||
* The instances are rigorously defined (i.e. you have guidelines for telling wheter a cell is or isn't an instance of that class) | |||
* The class' instances are present in a specific taxon | |||
* The class is considered useful by any research project. | |||
Some subdefinitions help to organize it. | |||
Note that these are not considered axioms, as the second (* The class' instances are present in a specific taxon) can be partially inferred from the first, as this might be needed for a rigorous definition. | |||
== Subdefinitions == | |||
=== Cell archetype === | |||
A cell type defined for more than one species, e.g. "neuron") | |||
=== Cell type ''strictu sensu'' === | |||
A cell type defined for one taxon (e.g. "human neuron") | |||
=== Cell infratype === | |||
A cell type defined for a taxon below the species level (e.g. "C57BL/6J mice neuron") | |||
=== Technotype === | |||
A cell type that rigorously corresponds to what is being measured in a given experiment ("ex: CD4+ CD8- FACS-sorted C57BL/6J mice cell") | |||
Properties | = Core items and properties = | ||
== Items == | |||
* [[Item:Q2|archetype]] | |||
* [[Item:Q3|cell type (strictu sensu)]] | |||
* [[Item:Q6|technotype]] | |||
* [[Item:Q10|cell type (latu sensu)]] | |||
Which are all instances of: | |||
* [[Item:Q11|class of cell classes]] | |||
== Properties == | |||
== Basic classification properties == | |||
* [[Property:P1|instance of]] (e.g. a "human neuron" is an instance of "cell type (strictu sensu)") | |||
* [[Property:P2|subclass of]] (e.g. a "human neuron" is a subclass of "neuron") | |||
* [[Property:P8|Wikidata ID]] Close match on Wikidata (similar to [https://www.w3.org/TR/skos-reference/#L4858 skos:closeMatch]) | |||
== Cell type specific properties == | |||
These are properties that all items for instances of cell types should have | |||
=== Definition properties === | |||
These properties have the weight of complete definitions. They are indisputable, as they are part of the definition of the class. Changing definitions is advisable only for clarifications. | |||
The real-world existence might be challenged, but this is still unmodelled. | |||
* [[Property:P5|has scope]] - the taxon or taxons in the scope for this conceptualization of cell type (e.g. "human neuron" has scope "Homo sapiens") | |||
* [[Property:P6|natural language definition]] - a natural language definition of this cell type. (e.g. "human neuron" has natural language definition "cells capable of transmitting electrical impulses). | |||
** Note that the natural language definition will likely have some ambiguity, as this is a feature of natural languages. Ideally, the description should be described by dedicated properties, allowing computable definitions, but this is an arduous, at least decade-long task. The scope doesn't need to be stated again in the natural language definition, as it is already parsed my [[Property:P5|has scope]]. | |||
=== Description properties === | |||
These properties serve to describe the classes defined by the properties above. They are disputable, and may be seem as hypothesis regarding the defined cell types. | |||
== Model items == | |||
* [[Item:Q19|Type 2 AS DC (Technotype / Villani et al, 2017)]] |